primary cells

The demand for hepatocytes is met by many of the major commercial suppliers [e.g., Lonza, Gibco (Life Technologies)] as well as entities with a near exclusive focus on the needs of ADME/Toxicology researchers [e.g., Xenotech, Celsis IVT, BD Gentest (Corning Life Sciences)].

primary cells

We also found that peripheral blood mononuclear cells (PMBCs), fibroblasts from various tissues and neurons are the most frequently used types of primary cells, and that there is very little difference between academic and industrial respondents in terms of cell types used with the exception of primary hepatocytes. 23% of the industrial respondents cite the use of hepatocytes, making them the second most widely used cell type in this segment.